[11C]acetate PET/CT Visualizes Skeletal Muscle Exercise Participation, Impaired Function, and Recovery after Hip Arthroplasty; First Results
Franz Buchegger,corresponding author1 Osman Ratib,1 Jean-Pierre Willi,1 Charles Steiner,1 Yann Seimbille,1 Habib Zaidi,1 Véronique Graf,2 Robin Peter,2 and Maximilien Jung2Hip
Purpose
Based on skeletal muscle acetate physiology we aimed studying muscle function after hip arthroplasty with [11C]acetate PET.
Procedures
Two male patients were investigated 3 and 12 weeks after hip arthroplasty with muscle [11C]acetate PET/CT performed at rest and exercise. Median muscle SUVmean were calculated on three non-consecutive transverse PET slices.
Results
The four exercise PET/CT showed, compared with rest, consistent increase in [11C]acetate uptake in active muscles contralateral to surgery. On the arthroplasty side most muscles showed symmetric activity increase under exercise both at 3 and 12 weeks after surgery, but four muscles showed only minor activity increase at 3 weeks. At 3 months, functional recovery of the latter four muscles was observed.
Conclusion
Consistent increase in [11C]acetate uptake in healthy muscles under exercise compared with rest was observed by PET/CT. Transiently impaired muscle function 3 weeks after surgery recovered at 3 months. These first observations merit further investigation.
Link to article