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EFORT Open Reviews 2016 1:7, 275-278
Hip Knee
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The role of biomarkers in the diagnosis of periprosthetic joint infection
AliSina Shahi, Javad ParviziHip Knee
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The role of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first line for evaluating a patient with periprosthetic joint infection (PJI) has been debunked.
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We are living in the era of biomarkers for the diagnosis of PJI, and to that effect, several biomarkers have been introduced such as synovial fluid alpha defensin and leukocyte esterase.
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The synovial fluid leukocyte esterase test has a low cost, is accessible, and has provided promising results for diagnosing PJI.
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There is an urgent need for an accurate and reliable serum biomarker for diagnosing patients with PJI.
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