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Acta Orthopaedica Scandinavica, 72:5, 499-502
Knee
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The effect of flurbiprofen and tiaprofenic acid on serum cytokine levels of patients with osteoarthrosis
Hafize Uzun, Sansin Tuzun, Nihal Ozaras, Seval Aydin, Resat Ozaras, Safiye Dondurmaci & Fikret TuzunKnee
39 patients with active knee osteoarthrosis, chosen according to ACR criteria, were assigned to receive flurbiprofen (n 12, 2 2 100 mg), tiaprofenic acid (n 14, 2 2 300 mg) and placebo (n 13) in a 3-week, placebo-controlled study. All patients completed the study, and both medications were found to be effective: improvement occurred in the clinical signs. These drugs reduced the TNF- f levels. Flurbiprofen especially affected the IL-6 levels. Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis.
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