A total of 165,474 patients met inclusion criteria. The mean (±standard deviation) operative time was 91.9 ± 32.5 minutes. Following adjustment for baseline characteristics, an increase in operative time by 15 minutes increased the risk of anemia requiring transfusion by 9% (95% confidence interval [CI] = 8%-10%, P < .001), wound dehiscence by 13% (95% CI = 8%-19%, P < .001), renal insufficiency by 9% (95% CI = 3%-14%, P < .001), sepsis by 10% (95% CI = 6%-14%, P < .001), surgical site infection by 9% (95% CI = 7%-12%, P < .001), and urinary tract infection by 4% (95% CI = 2%-6%, P < .001). Similarly, an increase in operative time by 15 minutes increased the risk of hospital readmission by 5% (95% CI = 4%-6%, P < .001) and of extended hospital length of stay (≥4 days) by 9% (95% CI = 8%-10%, P < .001).