Fibrin sealants in orthopaedic surgery: practical experiences derived from use of QUIXIL® in total knee arthroplasty
Kluba, T., Fiedler, K., Kunze, B. et al.Knee
Background
Total knee arthroplasty is associated with a significant postoperative blood loss even without any form of perioperative anticoagulation.
Methods
The potential role of QUIXIL®, a fibrin sealant used in orthopaedic surgery to control blood loss and avoid blood transfusions in patients undergoing total knee arthroplasty was evaluated in a prospective randomized trial with twenty-four patients diagnosed with primary osteoarthritis of the knee.
Results
Results showed that application of 2 ml QUIXIL® adds costs to treatment without reducing the number of transfused red blood cell counts and postoperative haemoglobin loss. However, significant lower levels of postoperative fluid loss (P = 0.026) was detected in QUIXIL® treated patients.
Conclusion
Regarding cost effectiveness and benefit no indication for the use of 2 ml QUIXIL® fibrin sealant in standard knee arthroplasty could be proofed statistically.
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