Arthroplasty. 2019; 1: 13

Efficacy of pre-emptive use of cyclooxyenase-2 inhibitors for total knee arthroplasty: a mini-review

Jianda Xu,#1 Huan Li,#2 Chong Zheng,1 Bin Wang,1 Pengfei Shen,1 Zikang Xie,1 and Yuxing Qu1

Knee

Total knee arthroplasty (TKA) is regarded as the most effective surgery for patients with later-stage arthritis of the knee, but the postoperative pain management for functional improvement of the knew is still a challenging task. This review discusses the mechanism by which the selective cyclooxyenase-2 inhibitors, which reduce the peripheral and central sensitization, decrease pain after TKA. This review also covers the protocols, safety, efficacy, and progress of cyclooxyenase-2 inhibitors in pre-emptive analgesia.

Keywords: Cyclooxyenase-2 inhibitors, Pre-emptive analgesia, Total knee arthroplasty

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