Antimicrobial Efficacy of Five Commercially Available Antibiotic Bone Cements: An In Vitro Comparison

Antibiotic bone cement (PMMA) can be used for primary total knee arthroplasty/total hip arthroplasty infection prophylaxis as well as treatment and reconstruction of septic total knee arthroplasty/total hip arthroplasty. To date, no investigation has compared antimicrobial efficacies of commercially available, “pre-mixed” antibiotic PMMAs. This study compares the in vitro antibacterial activity of 5 antibiotic PMMA formulations.